Improved Survival in Rhesus Macaques Immunized with Modified Vaccinia Virus Ankara Recombinants Expressing Simian Immunodeficiency Virus Envelope Correlates with Reduction in Memory CD4(+) T-Cell Loss and Higher Titers of Neutralizing Antibody

Previous studies demonstrated that immunization of macaques with simian immunodeficiency virus (SIV) Gag-Pol and Env recombinants of the attenuated poxvirus modified vaccinia virus Ankara (MVA) provided protection from high viremia and AIDS following challenge with a pathogenic strain of SIV. Althou...

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Détails bibliographiques
Auteurs principaux: Ourmanov, Ilnour, Kuwata, Takeo, Goeken, Robert, Goldstein, Simoy, Iyengar, Ranjani, Buckler-White, Alicia, Lafont, Bernard, Hirsch, Vanessa M.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681965/
https://ncbi.nlm.nih.gov/pubmed/19321617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02598-08
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