Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors

BACKGROUND: TRPA1 has been implicated in both chemo- and mechanosensation. Recent work demonstrates that inhibiting TRPA1 function reduces mechanical hypersensitivity produced by inflammation. Furthermore, a broad range of chemical irritants require functional TRPA1 to exert their effects. In this s...

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Main Authors: Kerstein, Patrick C, del Camino, Donato, Moran, Magdalene M, Stucky, Cheryl L
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2009
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681449/
https://ncbi.nlm.nih.gov/pubmed/19383149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-5-19
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