Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K

Rat cardiac fibroblasts (CF) express multiple adenosine (ADO) receptors. Pharmacological evidence suggests that activation of A(2) receptors may inhibit collagen synthesis via adenylyl cyclase-induced elevation of cellular cAMP. We have characterized the signaling pathways involved in ADO-mediated i...

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Detalhes bibliográficos
Main Authors: Villarreal, Francisco, Epperson, Sara A., Ramirez-Sanchez, Israel, Yamazaki, Katrina G., Brunton, Laurence L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Extracellular Matrix, Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681376/
https://ncbi.nlm.nih.gov/pubmed/19279233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00291.2008
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