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Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway
Nephrotoxicity is the major limiting factor for the use of cisplatin in cancer therapy. Recent studies have demonstrated an important role for p53 in cisplatin-induced renal injury. Nevertheless, pharmacological and genetic blockade of p53 only provides partial renoprotective effects, suggesting the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2681364/ https://ncbi.nlm.nih.gov/pubmed/19279129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90579.2008 |
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