Inhibition of Cystine Uptake Disrupts the Growth of Primary Brain Tumors

Glial cells play an important role in sequestering neuronally released glutamate via Na(+)-dependent transporters. Surprisingly, these transporters are not operational in glial-derived tumors (gliomas). Instead, gliomas release glutamate, causing excitotoxic death of neurons in the vicinity of the t...

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Autori principali: Chung, Wook Joon, Lyons, Susan A., Nelson, Gina M., Hamza, Hashir, Gladson, Candece L., Gillespie, G. Yancey, Sontheimer, Harald
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2005
Soggetti:
Neurobiology of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681064/
https://ncbi.nlm.nih.gov/pubmed/16079392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5258-04.2005
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