Structure-Based Stabilization of HIV-1 gp120 Enhances Humoral Immune Responses to the Induced Co-Receptor Binding Site

The human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein, gp120, possesses conserved binding sites for interaction with the primary virus receptor, CD4, and also for the co-receptor, generally CCR5. Although gp120 is a major target for virus-specific neutralizing antibodies, th...

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Detalhes bibliográficos
Main Authors: Dey, Barna, Svehla, Krisha, Xu, Ling, Wycuff, Dianne, Zhou, Tongqing, Voss, Gerald, Phogat, Adhuna, Chakrabarti, Bimal K., Li, Yuxing, Shaw, George, Kwong, Peter D., Nabel, Gary J., Mascola, John R., Wyatt, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680979/
https://ncbi.nlm.nih.gov/pubmed/19478876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000445
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