Full Factorial Analysis of Mammalian and Avian Influenza Polymerase Subunits Suggests a Role of an Efficient Polymerase for Virus Adaptation

Amongst all the internal gene segments (PB2. PB1, PA, NP, M and NS), the avian PB1 segment is the only one which was reassorted into the human H2N2 and H3N2 pandemic strains. This suggests that the reassortment of polymerase subunit genes between mammalian and avian influenza viruses might play role...

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Detalhes bibliográficos
Main Authors: Li, Olive T. W., Chan, Michael C. W., Leung, Cynthia S. W., Chan, Renee W. Y., Guan, Yi, Nicholls, John M., Poon, Leo L. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680953/
https://ncbi.nlm.nih.gov/pubmed/19462010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005658
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