Accumulating Progenitor Cells in the Luminal Epithelial Cell Layer Are Candidate Tumor Initiating Cells in a Pten Knockout Mouse Prostate Cancer Model

The PSA-Cre;Pten-loxP/loxP mouse prostate cancer model displays clearly defined stages of hyperplasia and cancer. Here, the initial stages of hyperplasia development are studied. Immunohistochemical staining showed that accumulated pAkt(+) hyperplastic cells overexpress luminal epithelial cell marke...

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Detalhes bibliográficos
Main Authors: Korsten, Hanneke, Ziel-van der Made, Angelique, Ma, Xiaoqian, van der Kwast, Theo, Trapman, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680948/
https://ncbi.nlm.nih.gov/pubmed/19461893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005662
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