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An HSV-1 gD mutant virus as an entry-impaired live virus vaccine
HSV-1 glycoprotein D (gD) interacts with HVEM and nectin-1 cell receptors to initiate virus entry. We prepared an HSV-1 strain with mutations in the gD gene at amino acid residues 3 and 38 by changing alanine to cysteine and tyrosine to cysteine, respectively (A3C/Y38C). These mutations were constru...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680698/ https://ncbi.nlm.nih.gov/pubmed/18243431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.12.032 |
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