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Dual Mechanisms of CYP3A Protein Regulation by Proinflammatory Cytokine Stimulation in Primary Hepatocyte Cultures

Whereas many cytochrome P450 enzymes are transcriptionally suppressed by inflammatory stimuli, down-regulation of CYP2B protein by the inflammatory cytokine interleukin (IL)-1β is nitric oxide (NO)-dependent and occurs via polyubiquitination and proteasomal degradation. Here, we used iTRAQ proteomic...

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Detalhes bibliográficos
Main Authors: Lee, Choon-Myung, Pohl, Jan, Morgan, Edward T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680532/
https://ncbi.nlm.nih.gov/pubmed/19171675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.026187
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