Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption

Cholic acid (CA) feeding of farnesoid X receptor (Fxr)-null mice results in markedly elevated hepatic bile acid levels and liver injury. In contrast, Fxr-null mice fed cholesterol plus CA (CA+Chol) do not exhibit liver injury, and hepatic bile acid levels and bile acid pool size are reduced 51 and 4...

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Bibliografiset tiedot
Päätekijät: Miyata, Masaaki, Matsuda, Yoshiki, Nomoto, Masahiro, Takamatsu, Yuki, Sato, Nozomi, Hamatsu, Mayumi, Dawson, Paul A., Gonzalez, Frank J., Yamazoe, Yasushi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680521/
https://ncbi.nlm.nih.gov/pubmed/18988759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.022590
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