Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury

Heme oxygenase (HO) catalyzes the conversion of heme to carbon monoxide, iron, and biliverdin, which is immediately reduced to bilirubin (BR). Two HO active isozymes exist: HO1, an inducible heat shock protein, and HO2, which is constitutive and highly concentrated in neurons. We demonstrate a neuro...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Doré, Sylvain, Takahashi, Masaaki, Ferris, Christopher D., Hester, Lynda D., Guastella, Daniel, Snyder, Solomon H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26804/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051662/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.2445
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