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Interactions of platelet integrin α(ΙΙb) and β(3) transmembrane domains in mammalian cell membranes and their role in integrin activation

Clustering and occupancy of platelet integrin α(IIb)β(3) (GPIIb-IIIa) generate biologically important signals: conversely, intracellular signals increase the integrins' affinity, leading to integrin activation; both forms of integrin signaling play important roles in hemostasis and thrombosis....

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Main Authors: Kim, Chungho, Lau, Tong-Lay, Ulmer, Tobias S., Ginsberg, Mark H.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680374/
https://ncbi.nlm.nih.gov/pubmed/19218549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-10-186551
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