Binding optimization through coordination chemistry: CXCR4 chemokine receptor antagonists from ultra rigid metal complexes

[Image: see text] A new copper(II) containing bis-macrocyclic CXCR4 chemokine receptor antagonist is shown to have improved binding properties to the receptor protein in comparison to the drug AMD3100 (Plerixafor, Mozobil(™)). The interaction of the metallodrug has been optimized by using ultra rigi...

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Détails bibliographiques
Auteurs principaux: Khan, Abid, Nicholson, Gary, Greenman, John, Madden, Leigh, McRobbie, Graeme, Pannecouque, Christophe, De Clercq, Erik, Ullom, Robert, Maples, Danny L., Maples, Randall L., Silversides, Jon D., Hubin, Timothy J., Archibald, Stephen J.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680178/
https://ncbi.nlm.nih.gov/pubmed/19231846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja807921k
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