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Caged Protein Prenyltransferase Substrates: Tools for Understanding Protein Prenylation

Originally designed to block the prenylation of oncogenic Ras, inhibitors of protein farnesyltransferase currently in pre-clinical and clinical trials are showing efficacy in cancers with normal Ras. Blocking protein prenylation has also shown promise in the treatment of malaria, Chagas disease, and...

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Detalhes bibliográficos
Main Authors: DeGraw, Amanda J., Hast, Michael A., Xu, Juhua, Mullen, Daniel, Beese, Lorena S., Barany, George, Distefano, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680146/
https://ncbi.nlm.nih.gov/pubmed/18844669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2008.00698.x
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