Pharmacokinetics of Efavirenz when Co-administered with Rifampin in TB/HIV Co-infected Patients: Pharmacogenetic Effect of CYP2B6 Variation

The goal of this study was to determine the effect of CYP2B6 genetic variation on the steady-state pharmacokinetics of efavirenz (600 mg/day) in TB/HIV co-infected patients receiving concomitant rifampin, a potent CYP inducer. In the 26 patients studied, CYP2B6 c.516GG, GT and TT genotype frequencie...

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Hauptverfasser: Kwara, Awewura, Lartey, Margaret, Sagoe, Kwamena W., Xexemeku, Fafa, Kenu, Ernest, Oliver-Commey, Joseph, Boima, Vincent, Sagoe, Augustine, Boamah, Isaac, Greenblatt, David J., Court, Michael H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679896/
https://ncbi.nlm.nih.gov/pubmed/18728241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0091270008321790
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