Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC)

BACKGROUND: Protein used in medicine, e.g. interferon, are immunogenic and quickly broken down by the body. Pegylation is a recognized way of preserving their integrity and reducing immune reactions, and works well with enzymes used to degrade amino acids, a recent focus of attention in controlling...

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Bibliographische Detailangaben
Hauptverfasser: Tsui, Sam-Mui, Lam, Wai-Man, Lam, Tin-Lun, Chong, Hiu-Chi, So, Pui-Kin, Kwok, Sui-Yi, Arnold, Simon, Cheng, Paul Ning-Man, Wheatley, Denys N, Lo, Wai-Hung, Leung, Yun-Chung
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
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Primary Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679726/
https://ncbi.nlm.nih.gov/pubmed/19374748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-9-9
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