Sumoylation of PPARγ by apoptotic cells prevents LPS-induced NCoR removal from κB binding sites mediating transrepression of pro-inflammatory cytokines

Efficient clearance of apoptotic cells (AC) by professional phagocytes is crucial for tissue homeostasis and resolution of inflammation. Macrophages respond to AC with an increase in anti-inflammatory cytokine production, but a diminished release of pro-inflammatory mediators. Mechanisms to explain...

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Bibliographic Details
Main Authors: Jennewein, Carla, Kuhn, Anne-Marie, Schmidt, Martina Victoria, Meilladec-Jullig, Virginie, von Knethen, Andreas, Gonzalez, Frank J., Brüne, Bernhard
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679654/
https://ncbi.nlm.nih.gov/pubmed/18832723
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