Synthesis of (R)-3,4-dihydro-2H-pyran-2-carboxaldehyde: application to the synthesis of potent adenosine A(2A) and A(3) receptor agonist

Synthesis of potent adenosine A(2A) and A(3) receptor agonist from the modification of adenosine-5′-N-ethylcarboxamide (NECA) has been reported. Diastereoisomer possessing an (R) 3,4-dihydro-2H-pyranyl (DHP) moiety exhibited the highest affinity at the A(2A) and A(3) receptors. The key steps involve...

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Detalhes bibliográficos
Main Authors: Jagtap, Prakash G., Chen, Zhiyu, Koppetsch, Karsten, Piro, Elizabeth, Fronce, Paula, Southan, Garry J., Klotz, Karl-Norbert
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679502/
https://ncbi.nlm.nih.gov/pubmed/20161338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2009.03.148
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