The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1

Recently, Salmonella spp. were shown to induce apoptosis in infected macrophages. The mechanism responsible for this process is unknown. In this report, we establish that the Inv-Spa type III secretion apparatus target invasin SipB is necessary and sufficient for the induction of apoptosis. Purified...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Hersh, David, Monack, Denise M., Smith, Mark R., Ghori, Nafisa, Falkow, Stanley, Zychlinsky, Arturo
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1999
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26795/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051653/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.2396
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