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Domain Swapping Reveals That Low Density Lipoprotein (LDL) Type A Repeat Order Affects Ligand Binding to the LDL Receptor

The low density lipoprotein receptor (LDLR) plays a key role in plasma cholesterol homeostasis by binding and internalizing lipoprotein ligands. Studies have revealed that one or more of the seven LDL type A repeats (LA1–LA7) in the receptor are responsible for apolipoprotein binding. In the present...

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Bibliografiske detaljer
Main Authors: Yamamoto, Taichi, Ryan, Robert O.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679439/
https://ncbi.nlm.nih.gov/pubmed/19329437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900194200
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