Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships

BACKGROUND: Discovering that drug entities already approved for one disease are effective treatments for other distinct diseases can be highly beneficial and cost effective. To do this predictively, our conjecture is that a semantic infrastructure linking mechanistic relationships between pharmacolo...

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Main Authors: Qu, Xiaoyan A, Gudivada, Ranga C, Jegga, Anil G, Neumann, Eric K, Aronow, Bruce J
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2009
Assuntos:
Proceedings
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679404/
https://ncbi.nlm.nih.gov/pubmed/19426461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-S5-S4
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