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Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships

BACKGROUND: Discovering that drug entities already approved for one disease are effective treatments for other distinct diseases can be highly beneficial and cost effective. To do this predictively, our conjecture is that a semantic infrastructure linking mechanistic relationships between pharmacolo...

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Bibliografiske detaljer
Main Authors: Qu, Xiaoyan A, Gudivada, Ranga C, Jegga, Anil G, Neumann, Eric K, Aronow, Bruce J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679404/
https://ncbi.nlm.nih.gov/pubmed/19426461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-S5-S4
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