Conformational Preferences of α-Substituted Proline Analogues

DFT calculations at the B3LYP/6-31+G(d,p) level have been used to investigate how the replacement of the α hydrogen by a more sterically demanding group affects the conformational preferences of proline. Specifically, the N-acetyl-N’-methylamide derivatives of L-proline, L-α-methylproline and L-α-ph...

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Bibliografiska uppgifter
Huvudupphovsmän: Flores-Ortega, Alejandra, Jiménez, Ana I., Cativiela, Carlos, Nussinov, Ruth, Alemán, Carlos, Casanovas, Jordi
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679371/
https://ncbi.nlm.nih.gov/pubmed/18351745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo702710x
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