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Quantitation of DNA methylation by melt curve analysis

BACKGROUND: Methylation of DNA is a common mechanism for silencing genes, and aberrant methylation is increasingly being implicated in many diseases such as cancer. There is a need for robust, inexpensive methods to quantitate methylation across a region containing a number of CpGs. We describe and...

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Hlavní autoři: Smith, Eric, Jones, Michael E, Drew, Paul A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679043/
https://ncbi.nlm.nih.gov/pubmed/19393074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-123
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