Interferon γ expressed by a recombinant respiratory syncytial virus attenuates virus replication in mice without compromising immunogenicity

Interferon γ (IFN-γ) has pleiotropic biological effects, including intrinsic antiviral activity as well as stimulation and regulation of immune responses. An infectious recombinant human respiratory syncytial virus (rRSV/mIFN-γ) was constructed that encodes murine (m) IFN-γ as a separate gene insert...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bukreyev, Alexander, Whitehead, Stephen S., Bukreyeva, Natalya, Murphy, Brian R., Collins, Peter L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26790/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051648/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.2367
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