Biotinylation of Histones Represses Transposable Elements in Human and Mouse Cells and Cell Lines and in Drosophila melanogaster

Transposable elements such as long terminal repeats (LTR) constitute ∼45% of the human genome; transposition events impair genome stability. Fifty-four promoter-active retrotransposons have been identified in humans. Epigenetic mechanisms are important for transcriptional repression of retrotranspos...

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Main Authors: Chew, Yap Ching, West, John T., Kratzer, Stephanie J., Ilvarsonn, Anne M., Eissenberg, Joel C., Dave, Bhavana J., Klinkebiel, David, Christman, Judith K., Zempleni, Janos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Nutrition 2008
Assuntos:
Biochemical, Molecular, and Genetic Mechanisms
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678950/
https://ncbi.nlm.nih.gov/pubmed/19022951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.108.098673
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