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Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling

The 3 Akt protein kinase isoforms have critical and distinct functions in the regulation of metabolism, cell growth, and apoptosis, yet the mechanisms by which their signaling specificity is achieved remain largely unclear. Here, we investigated potential mechanisms underlying Akt isoform functional...

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Detalhes bibliográficos
Main Authors: Gonzalez, Eva, McGraw, Timothy E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678468/
https://ncbi.nlm.nih.gov/pubmed/19372382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901933106
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