Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes

Homologous flavoproteins from the photolyase (PHR)/cryptochrome (CRY) family use the FAD cofactor in PHRs to catalyze DNA repair and in CRYs to tune the circadian clock and control development. To help address how PHR/CRY members achieve these diverse functions, we determined the crystallographic st...

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Détails bibliographiques
Auteurs principaux: Hitomi, Kenichi, DiTacchio, Luciano, Arvai, Andrew S., Yamamoto, Junpei, Kim, Sang-Tae, Todo, Takeshi, Tainer, John A., Iwai, Shigenori, Panda, Satchidananda, Getzoff, Elizabeth D.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678464/
https://ncbi.nlm.nih.gov/pubmed/19359474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809180106
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