A Ca(2+)–calmodulin–eEF2K–eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions

Skeletal muscle protein synthesis rate decreases during contractions but the underlying regulatory mechanisms are poorly understood. It was hypothesized that there would be a coordinated regulation of eukaryotic elongation factor 2 (eEF2) and eukaryotic initiation factor 4E-binding protein 1 (4EBP1)...

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Bibliographic Details
Main Authors: Rose, Adam J, Alsted, Thomas J, Jensen, Thomas E, Kobberø, J Bjarke, Maarbjerg, Stine J, Jensen, Jørgen, Richter, Erik A
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2009
Subjects:
Skeletal Muscle and Exercise
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678225/
https://ncbi.nlm.nih.gov/pubmed/19188248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.167528
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