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Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis

Muscle protein synthesis and mTORC1 signalling are concurrently stimulated following muscle contraction in humans. In an effort to determine whether mTORC1 signalling is essential for regulating muscle protein synthesis in humans, we treated subjects with a potent mTORC1 inhibitor (rapamycin) prior...

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Détails bibliographiques
Auteurs principaux: Drummond, Micah J, Fry, Christopher S, Glynn, Erin L, Dreyer, Hans C, Dhanani, Shaheen, Timmerman, Kyle L, Volpi, Elena, Rasmussen, Blake B
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2009
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678224/
https://ncbi.nlm.nih.gov/pubmed/19188252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.163816
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