In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality

The pacemaker current, mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, contributes to the initiation and regulation of cardiac rhythm. Previous experiments creating HCN-based biological pacemakers in vivo found that an engineered HCN2/HCN1 chimeric channel (HCN212) re...

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Main Authors: Zhao, Xin, Bucchi, Annalisa, Oren, Ronit V, Kryukova, Yelena, Dun, Wen, Clancy, Colleen E, Robinson, Richard B
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2009
主題:
Cardiovascular
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678222/
https://ncbi.nlm.nih.gov/pubmed/19171659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.163444
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