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In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality
The pacemaker current, mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, contributes to the initiation and regulation of cardiac rhythm. Previous experiments creating HCN-based biological pacemakers in vivo found that an engineered HCN2/HCN1 chimeric channel (HCN212) re...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Science Inc
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2678222/ https://ncbi.nlm.nih.gov/pubmed/19171659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.163444 |
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