Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells

Select changes in microRNA (miRNA) expression correlate with estrogen receptor α (ERα) expression in breast tumors. miR-21 is higher in ERα positive than negative tumors, but no one has examined how estradiol (E(2)) regulates miR-21 in breast cancer cells. Here we report that E(2) inhibits miR-21 ex...

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Autores principales: Wickramasinghe, Nalinie S., Manavalan, Tissa T., Dougherty, Susan M., Riggs, Krista A., Li, Yong, Klinge, Carolyn M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
RNA
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677875/
https://ncbi.nlm.nih.gov/pubmed/19264808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp117
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