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Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

Streptozotocin (STZ), a glucose analogue known to induce diabetes in experimental animals, causes DNA strand breaks and subsequent activation of poly(ADPribose) polymerase (Parp). Because Parp uses NAD as a substrate, extensive DNA damage will result in reduction of cellular NAD level. In fact, STZ...

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Wedi'i Gadw mewn:
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Masutani, Mitsuko, Suzuki, Hiroshi, Kamada, Nobuo, Watanabe, Miho, Ueda, Otoya, Nozaki, Tadashige, Jishage, Kou-ichi, Watanabe, Takeshi, Sugimoto, Tetsuro, Nakagama, Hitoshi, Ochiya, Takahiro, Sugimura, Takashi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1999
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26778/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051636/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.2301
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