Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

Streptozotocin (STZ), a glucose analogue known to induce diabetes in experimental animals, causes DNA strand breaks and subsequent activation of poly(ADPribose) polymerase (Parp). Because Parp uses NAD as a substrate, extensive DNA damage will result in reduction of cellular NAD level. In fact, STZ...

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Detalhes bibliográficos
Main Authors: Masutani, Mitsuko, Suzuki, Hiroshi, Kamada, Nobuo, Watanabe, Miho, Ueda, Otoya, Nozaki, Tadashige, Jishage, Kou-ichi, Watanabe, Takeshi, Sugimoto, Tetsuro, Nakagama, Hitoshi, Ochiya, Takahiro, Sugimura, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC26778/
https://ncbi.nlm.nih.gov/pubmed/10051636
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