Leucine-Rich Repeat Kinase 2 Colocalizes with α-Synuclein in Parkinson's Disease, but Not Tau-Containing Deposits in Tauopathies

BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease. OBJECTIVE: To examine whether LRRK2 is directly associated with the pathological structures of Parkinson's disea...

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Autors principals: Perry, George, Zhu, Xiongwei, Babar, Asim K., Siedlak, Sandra L., Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, Smith, Mark A., Chen, Shu G.
Format: Artigo
Idioma:Inglês
Publicat: S. Karger AG 2008
Matèries:
Alpha-Synuclein
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677749/
https://ncbi.nlm.nih.gov/pubmed/18322396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000113708
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