The A(3) Adenosine Receptor Agonist CF502 Inhibits the PI3K, PKB/Akt and NF-κB Signaling Pathway in Synoviocytes from Rheumatoid Arthritis Patients and in Adjuvant Induced Arthritis Rats

The A(3) adenosine receptor (A(3)AR) is over-expressed in inflammatory cells and was defined as a target to combat inflammation. Synthetic agonists to this receptor, such as IB-MECA and Cl-IB-MECA, exert an anti-inflammatory effect in experimental animal models of adjuvant and collagen induced arthr...

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Main Authors: Ochaion, A., Bar-Yehuda, S., Cohen, S., Amital, H., Jacobson, K.A., Joshi, B.V., Gao, Z.G., Barer, F., Patoka, R., Del Valle, L., Perez-Liz, G., Fishman, P.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677448/
https://ncbi.nlm.nih.gov/pubmed/18602896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.05.032
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