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MMPs as therapeutic targets – still a viable option?

Matrix metalloproteinases (MMPs) appear to be ideal drug targets – they are disease-associated, extracellular enzymes with a dependence on zinc for activity. This apparently straightforward target, however, is much more complex than initially realized. Although disease associated, the roles for part...

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Bibliographic Details
Main Author: Fingleton, Barbara
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677300/
https://ncbi.nlm.nih.gov/pubmed/17693104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2007.06.006
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