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Peptide Cyclization and Cyclodimerization by Cu(I)-Mediated Azide-Alkyne Cycloaddition
Head-to-tail cyclodimerization of resin-bound oligopeptides bearing azide and alkyne groups occurs readily by 1,3-dipolar cycloaddition upon treatment with Cu(I). The process was found to be independent of peptide sequence, sensitive to the proximity of the alkyne to the resin, sensitive to solvent...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2677176/ https://ncbi.nlm.nih.gov/pubmed/19309103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo802097m |
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