BMP15 mutations associated with Primary Ovarian Insufficiency cause a defective production of bioactive protein

BMP15 is selectively synthesized by oocytes as a pre-proprotein and is considered an ovarian follicle organizer whose adequate function is critical for female fertility. Missense mutations were reported in Primary Ovarian Insufficiency (POI) but their biological impact remained unexplored. Here, scr...

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Hlavní autoři: Rossetti, Raffaella, Di Pasquale, Elisa, Marozzi, Anna, Bione, Silvia, Toniolo, Daniela, Grammatico, Paola, Nelson, Lawrence M., Beck-Peccoz, Paolo, Persani, Luca
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677132/
https://ncbi.nlm.nih.gov/pubmed/19263482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.20961
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