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Attenuated Response to In Vivo Mechanical Loading in Mice With Conditional Osteoblast Ablation of the Connexin43 Gene (Gja1)

INTRODUCTION: In vitro data suggest that gap junctional intercellular communication mediated by connexin43 (Cx43) plays an important role in bone cell response to mechanical stimulation. We tested this hypothesis in vivo in a model of genetic deficiency of the Cx43 gene (Gja1). MATERIALS AND METHODS...

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Detalhes bibliográficos
Main Authors: Grimston, Susan K, Brodt, Michael D, Silva, Matthew J, Civitelli, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Amer Soc Bone & Mineral Res. 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677086/
https://ncbi.nlm.nih.gov/pubmed/18282131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.080222
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