MRI correlates of neurofibrillary tangle pathology at autopsy: A voxel-based morphometry study

BACKGROUND: Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins, are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine whether patterns of gray matter atrophy from antemortem MRI correlate with Braak staging of NFT pathology. METHODS: Eighty-th...

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Autors principals: Whitwell, J L., Josephs, K A., Murray, M E., Kantarci, K, Przybelski, S A., Weigand, S D., Vemuri, P, Senjem, M L., Parisi, J E., Knopman, D S., Boeve, B F., Petersen, R C., Dickson, D W., Jack, C R.
Format: Artigo
Idioma:Inglês
Publicat: American Academy of Neurology 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676950/
https://ncbi.nlm.nih.gov/pubmed/18765650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/01.wnl.0000324924.91351.7d
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