SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage

Genotoxic agents such as ionizing radiation trigger cell cycle arrest at the G1/S and G2/M checkpoints, allowing cells to repair damaged DNA before entry into mitosis. DNA damage-induced G1 arrest involves p53-dependent expression of p21 (Cip1/Waf-1), which inhibits cyclin-dependent kinases and bloc...

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Bibliografiske detaljer
Main Authors: Sitko, John C., Yeh, Brian, Kim, Moonhong, Zhou, Hong, Takaesu, Giichi, Yoshimura, Akihiko, McBride, William H., Jewett, Anahid, Jamieson, Christina A.M., Cacalano, Nicholas A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676910/
https://ncbi.nlm.nih.gov/pubmed/18793717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2008.08.011
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