COMPARISON OF CITRUS COUMARINS ON CARCINOGEN-DETOXIFYING ENZYMES IN NRF2 KNOCKOUT MICE

Naturally occurring coumarins possess anti-carcinogenic activities in part by inducing carcinogen-detoxifying enzymes glutathione S-transferase (GST) and/or NAD(P)H quinone oxidoreductase (NQO1). Our goal was to determine whether citrus coumarins induce hepatic GST and/or NQO1 via activation of Nrf2...

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Bibliografiske detaljer
Main Authors: Prince, Misty, Li, Yan, Childers, Asper, Itoh, Ken, Yamamoto, Masayuki, Kleiner, Heather E.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676710/
https://ncbi.nlm.nih.gov/pubmed/19150646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2008.12.014
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