Regulation of autophagy by cytoplasmic p53

Multiple cellular stressors, including activation of the tumour suppressor p53, can stimulate autophagy. Here we show that knockout, knockdown or pharmacological inhibition of p53 can induce autophagy in human, mouse and nematode cells. Enhanced autophagy improved the survival of p53-deficient cance...

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Huvudupphovsmän: Tasdemir, Ezgi, Maiuri, M. Chiara, Galluzzi, Lorenzo, Vitale, Ilio, Djavaheri-Mergny, Mojgan, D'Amelio, Marcello, Criollo, Alfredo, Morselli, Eugenia, Zhu, Changlian, Harper, Francis, Nannmark, Ulf, Samara, Chrysanthi, Pinton, Paolo, Vicencio, José Miguel, Carnuccio, Rosa, Moll, Ute M., Madeo, Frank, Paterlini-Brechot, Patrizia, Rizzuto, Rosario, Szabadkai, Gyorgy, Pierron, Gérard, Blomgren, Klas, Tavernarakis, Nektarios, Codogno, Patrice, Cecconi, Francesco, Kroemer, Guido
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676564/
https://ncbi.nlm.nih.gov/pubmed/18454141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1730
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