Regulation of autophagy by cytoplasmic p53

Multiple cellular stressors, including activation of the tumour suppressor p53, can stimulate autophagy. Here we show that knockout, knockdown or pharmacological inhibition of p53 can induce autophagy in human, mouse and nematode cells. Enhanced autophagy improved the survival of p53-deficient cance...

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Bibliografische gegevens
Hoofdauteurs: Tasdemir, Ezgi, Maiuri, M. Chiara, Galluzzi, Lorenzo, Vitale, Ilio, Djavaheri-Mergny, Mojgan, D'Amelio, Marcello, Criollo, Alfredo, Morselli, Eugenia, Zhu, Changlian, Harper, Francis, Nannmark, Ulf, Samara, Chrysanthi, Pinton, Paolo, Vicencio, José Miguel, Carnuccio, Rosa, Moll, Ute M., Madeo, Frank, Paterlini-Brechot, Patrizia, Rizzuto, Rosario, Szabadkai, Gyorgy, Pierron, Gérard, Blomgren, Klas, Tavernarakis, Nektarios, Codogno, Patrice, Cecconi, Francesco, Kroemer, Guido
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676564/
https://ncbi.nlm.nih.gov/pubmed/18454141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1730
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