Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications

Thiopeptides, with potent activity against various drug-resistant pathogens, contain a characteristic macrocyclic core consisting of multiple thiazoles, dehydroamino acids, and a 6-membered nitrogen heterocycle. Their biosynthetic pathways remain elusive in spite of great efforts by in vivo feeding...

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Main Authors: Liao, Rijing, Duan, Lian, Lei, Chun, Pan, Haixue, Ding, Ying, Zhang, Qi, Chen, Daijie, Shen, Ben, Yu, Yi, Liu, Wen
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676563/
https://ncbi.nlm.nih.gov/pubmed/19246004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.01.007
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