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The Mitochondrial Antioxidants MitoE(2) and MitoQ(10) Increase Mitochondrial Ca(2+) Load upon Cell Stimulation by Inhibiting Ca(2+) Efflux from the Organelle

Mitochondrial reactive oxygen species (ROS) production is recognized as a major pathogenic event in a number of human diseases, and mitochondrial scavenging of ROS appears a promising therapeutic approach. Recently, two mitochondrial antioxidants have been developed; conjugating α-tocopherol and the...

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Detalhes bibliográficos
Main Authors: Leo, Sara, Szabadkai, György, Rizzuto, Rosario
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676430/
https://ncbi.nlm.nih.gov/pubmed/19076448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1196/annals.1427.019
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