Induction of p21(CIP1/WAF1 )expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization

HTLV-1 Tax can induce senescence by up-regulating the levels of cyclin-dependent kinase inhibitors p21(CIP1/WAF1 )and p27(KIP1). Tax increases p27(KIP1 )protein stability by activating the anaphase promoting complex/cyclosome (APC/C) precociously, causing degradation of Skp2 and inactivation of SCF(...

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Detalhes bibliográficos
Main Authors: Zhang, Ling, Zhi, Huijun, Liu, Meihong, Kuo, Yu-Liang, Giam, Chou-Zen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676247/
https://ncbi.nlm.nih.gov/pubmed/19356250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-35
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