Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning

BACKGROUND: Caveolae, lipid-rich microdomains of the sarcolemma, localize and enrich cardiac protective signaling molecules. Caveolin-3 (Cav-3), the dominant isoform in cardiac myocytes, is a determinant of caveolae formation. We hypothesized that cardiac myocyte-specific overexpression of Cav-3 wou...

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Auteurs principaux: Tsutsumi, Yasuo M., Horikawa, Yousuke T., Jennings, Michelle M., Kidd, Michael W., Niesman, Ingrid R., Yokoyama, Utako, Head, Brian P., Hagiwara, Yasuko, Ishikawa, Yoshihiro, Miyanohara, Atsushi, Patel, Piyush M., Insel, Paul A., Patel, Hemal H., Roth, David M.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676165/
https://ncbi.nlm.nih.gov/pubmed/18936328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.788331
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