Proteolipid Protein Is Required for Transport of Sirtuin 2 into CNS Myelin

Mice lacking the expression of proteolipid protein (PLP)/DM20 in oligodendrocytes provide a genuine model for spastic paraplegia (SPG-2). Their axons are well myelinated but exhibit impaired axonal transport and progressive degeneration, which is difficult to attribute to the absence of a single mye...

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Hauptverfasser: Werner, Hauke B., Kuhlmann, Katja, Shen, Siming, Uecker, Marina, Schardt, Anke, Dimova, Kalina, Orfaniotou, Foteini, Dhaunchak, Ajit, Brinkmann, Bastian G., Möbius, Wiebke, Guarente, Lenny, Casaccia-Bonnefil, Patrizia, Jahn, Olaf, Nave, Klaus-Armin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2007
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676101/
https://ncbi.nlm.nih.gov/pubmed/17634366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1254-07.2007
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